| S^ | What's Up? |
| S2R | Send To Receive |
| S2U | Same To You |
| S4L | Spam For Life |
| SADAD | Suck A Dick And Die |
| SAHM | Stay At Home Mom |
| SBTA | Sorry, Being Thick Again |
| SBUG | Small Bald Unaudacious Goal |
| SCNR | Sorry, Could Not Resist |
| SED | Said Enough Darling |
| SEG | Sh** Eating Grin |
| SEP | Somebody Else's Problem |
| SETE | Smiling Ear To Ear |
| SEWAG | Scientifically Engineered Wild Ass Guess |
| SF | Surfer Friendly -or- Science Fiction |
| SFAIAA | So Far As I Am Aware |
| SFETE | Smiling From Ear To Ear |
| SFTTM | Stop F***ing Talking To Me |
| SFX | Sound Effects -or- Stage Effects |
| SH | Sh** Happens |
| SHB | Should Have Been |
| SHID | Slap Head In Disgust |
| SHMILY | See How Much I Love You |
| SIC | Spelling Is Correct |
| SICL | Sitting In Chair Laughing |
| SII | Seriously Impaired Imagination |
| SIL | Sister-In-Law |
| SIT | Stay In Touch |
| SITCOMs | Single Income, Two Children, Oppressive Mortgage |
| SITD | Still In The Dark |
| SIUP | Suck It Up Pussy |
| SIUYA | Shove It Up Your Ass |
| Sk8r | Skater |
| SL | Second Life |
| SLAP | Sounds Like A Plan |
| SLAW | Sounds Like A Winner |
| SLIRK | Smart Little Rich Kid |
| SLOM | Sticking Leeches On Myself |
| SLT | Something Like That |
| SM | Senior Moment |
| SMAIM | Send Me An Instant Message |
| SMB | Suck My Balls |
| SME | Subject Matter Expert |
| SMEM | Send Me E-Mail |
| SMH | Shaking My Head |
| SMIM | Send Me an Instant Message |
| SNAFU | Situation Normal, All F***ed Up |
| SNAG | Sensitive New Age Guy |
| SNERT | Snotty Nosed Egotistical Rotten Teenager |
| SO | Significant Other (spouse, boy/girlfriend) |
| SOB | Son Of a B*tch |
| SOGOP | Sh** Or Get Off the Pot |
| SOH | Sense Of Humor |
| SOHF | Sense Of Humor Failure |
| SOI | Self Owning Idiot |
| SOIAR | Sit On It And Rotate |
| SOL | Sh** Out of Luck |
| SOMY | Sick Of Me Yet |
| SOOYA | Snake Out Of Your Ass |
| SOP | Standard Operating Procedure |
| SorG | Straight or Gay |
| SOS | Same Old Sh** |
| SOT | Short On Time |
| SOTMG | Short On Time, Must Go |
| SRO | Standing Room Only |
| SSC | Super Sexy Cute |
| SSDD | Same Sh** Different Day |
| SSEWBA | Someday Soon, Everything Will Be Acronyms |
| STBY | Sucks To Be You |
| STD | Seal The Deal |
| STFU | Shut The F*** Up |
| STFW | Search The F***ing Web |
| STM | Spank The Monkey |
| STPPYNOZGTW | Stop Picking Your Nose, Get To Work |
| STR8 | Straight |
| STS | So To Speak |
| STW | Search The Web |
| STYS | Speak To You Soon |
| SU | Shut Up |
| SUAC | Sh** Up A Creek |
| SUAKM | Shut Up And Kiss Me |
| SUFI | Super Finger -or- Shut Up F***ing Imbecile |
| SUP | What's Up? |
| SUYF | Shut Up You Fool |
| SWAG | Scientific Wild Ass Guess -and- SoftWare And Giveaways |
| SWAK | Sealed (or Sent) With A Kiss |
| SWALBCAKWS | Sealed With A Lick Because A Kiss Won't Stick |
| SWALK | Sealed With A Loving Kiss |
| SWDYT | So What Do You Think |
| SWIS | See What I'm Saying |
| SWL | Screaming With Laughter |
| SWMBO | She Who Must Be Obeyed |
| SWU | So What's Up |
| SYS | See You Soon |
| SYT | See You Tomorrow |
|
